RS32
The RS32 Integrated Digital PCR System is a benchtop, high-precision molecular diagnostics tool designed for absolute quantification and rare mutation detection. With tens of thousands of partitions per run, dual/multi-color fluorescence detection, and fully integrated workflows, the RS32 delivers sensitivity down to 0.1% allele frequency and a dynamic range of up to 6 logs. It is ideally suited for oncology, infectious disease monitoring, genetic testing, and translational research, giving laboratories a powerful, user-friendly dPCR platform. Please Log In to access Additional Details and documents .. System Concept RS32 is an integrated digital PCR (dPCR) system, designed for high-sensitivity nucleic acid detection and absolute quantification. Provides an all-in-one solution for sample partitioning, amplification, and detection. Targets applications where precision, reproducibility, and ultra-low detection limits are critical. Core Features & Specifications Principle: Partition-based digital PCR — divides sample into thousands of nanoliter/microliter reaction units for endpoint amplification and absolute quantification. Partitions: Typically 20,000–30,000+ partitions per chip/well, ensuring statistical accuracy. Throughput: ~1–2 plates per run (depending on configuration). Detection Channels: Dual- or multi-color fluorescence channels (commonly FAM, VIC/HEX, CY5). Dynamic Range: 5–6 logs. Sensitivity: Detects rare alleles/mutations at ~0.1% frequency. Accuracy: Provides absolute quantification without reference standards. Workflow: Sample loading & partitioning (integrated chip/cartridge system). PCR amplification under precise thermal cycling. Fluorescence readout & analysis software. Sample Types: DNA, RNA (with reverse transcription), cfDNA, liquid biopsy, pathogen nucleic acids. Connectivity: Integrated analysis software; PC/LIS connectivity. Footprint: Benchtop compact system (approx. ~40–50 cm width). Advantages Ultra-sensitive detection: Ideal for low copy number targets and rare mutation analysis. Absolute quantification: Eliminates need for external standard curves (unlike qPCR). Integrated workflow: Combines partitioning, amplification, and detection in a single device → reduces hands-on time and contamination risk. Reproducible: High partition number ensures statistical confidence. Flexible: Supports pathogen detection, oncology, infectious disease monitoring, and liquid biopsy applications. Applications Oncology: Rare mutation and circulating tumor DNA (ctDNA) detection. Infectious disease: Viral load monitoring (e.g., HIV, HBV, SARS-CoV-2). Transplant medicine: Donor-derived cfDNA monitoring. Genetics: Copy number variation, SNP genotyping. Research: Gene expression quantification with high sensitivity.
(based on digital PCR systems in this class)